The proteomic profile of a mouse model of proliferative vitreoretinopathy
نویسندگان
چکیده
منابع مشابه
The proteomic profile of a mouse model of proliferative vitreoretinopathy
Proliferative vitreoretinopathy (PVR) develops as a complication of retinal detachment surgery and represents a devastating condition leading to serious vision loss. A good animal model that permits extensive functional studies and drug testing is crucial in finding better therapeutic modalities for PVR. A previously established mouse model, using dispase injection, was analyzed from the proteo...
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Proliferative Vitreoretinopathy and Genetic Profile
Proliferative vitreoretinopathy (PVR) is the principal cause of failure in retinal detachment (RD) surgery and is characterized by the proliferation of different cell types leading to the formation of cellular membranes on both sides of the retina. These membranes have the capability of contracture resulting in retinal redetachment. Despite marked improvement in vitreoretinal surgical technique...
متن کاملA new model of proliferative vitreoretinopathy.
PURPOSE To design a new model of proliferative vitreoretinopathy (PVR) that would not rely on the addition of exogenous cells. The release of endogenous cells from surrounding attachments seems to be an early event in the pathogenesis of PVR. Because the proteolytic enzyme dispase dissociates tissues, the hypothesis was that an intraocular injection of dispase could trigger events that would ca...
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ژورنال
عنوان ژورنال: FEBS Open Bio
سال: 2017
ISSN: 2211-5463
DOI: 10.1002/2211-5463.12252